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What Causes Migraines

March 7th, 2011
Richard Jensen, PhD asked:




            Migraine headaches have at one time or another affected over 15% of men and almost 30% of women (1). Over 20 million Americans suffer from either migraine or cluster headaches (2). For women, many migraine headaches are tied to their menstrual cycle. Migraine headaches usually affect women, while cluster headaches usually affect men. Symptoms of migraine headaches can include: rainbow-like colors or blank spots in one’s vision, severe head pain, fatigue, nausea and/or vomiting, and sensitivity to sounds and/or lights. Migraine symptoms are much different than the common tension headache, which affects 90% of headache sufferers. A tension headache is dull, affects both sides of the head, and is often associated with muscle tension around the neck.

            Causes of migraines can be many. Over one-third of headache sufferers say that alcohol intake is a main factor in causing their headache, and over half of migraine sufferers also point to alcohol as a culprit (3). Monosodium glutamate (MSG), a flavor enhancer used in many foods, changes blood vessel tone and blood flow, which may cause many migraine headaches. MSG can be disguised in food ingredient lists as “hydrolysed vegetable protein” or “natural flavor”. Nitrates, which are commonly found in cured meats, may also cause migraines (4). People with migraine headaches should try avoiding fermented aged, and yeast-containing foods, such as: baked yeast products, aged cheeses, sour cream, pickles, red wine, milk, chocolate, and cured meats like fermented sausages (5). Clinician Dr. Braly believes that almost all migraine headaches are aggravated by food allergies or sensitivities (1). Interestingly, migraine researcher Dr. Milne recommends that sufferers take two tablets of alka-seltzer immediately after symptoms appear.

            Since the pain of migraines can be intense, many sufferers choose to try different drugs for their condition. Lidocaine nose drops are sometimes used to stop migraine-induced sinus pain. Side effects of lidocaine include: confusion, vomiting, convulsions, unconsciousness, respiratory depression, and allergic reactions. One of the most common drug classes to treat migraines are the triptans (ex. Imitrex). Side effects of triptan drugs can include: heart attack, eye problems, and interactions with certain psychiatric drugs. Sometimes older antidepressants are used to help control migraines. This class of drugs, called tricyclic antidepressants, can be very dangerous to use, and overdose is often fatal. Other side effects can include: heart attack, stroke, hallucinations and/or delusions, hypomania, seizures, liver damage, and multiple drug interactions.

            Valproic acid (Depakene) is normally used as an anti-epileptic drug, but is sometimes used for migraines. Side effects of this drug can include: liver failure that has been fatal, abnormal blood clotting, deformed fetus in pregnant women, and possible increased risk of cancer. Gabapentin (Neurontin) is occasionally used to treat migraines. Side effects can include: withdrawal-induced seizures, cancer, unexplained death, and depression. Another off-label drug that can be used to treat migraines is methylsergide maleate (Sansert): side effects can include heart problems and seizures. Lithium Carbonate is normally used to control bipolar disorder, but is also sometimes used to help migraines. Side effects can include: kidney and heart problems, seizures, coma, hallucinations, and multiple drug interactions.

            Fortunately, there are many different nutritional supplements that can significantly help migraine headaches. The B-vitamins are important in brain function, and two of them can help migraines. Four hundred milligrams a day of riboflavin (vitamin B2) can help prevent migraines (6). At the above dose, over half of the study participants showed at least 50% improvement in their migraine symptoms (7). Supplementing with vitamin B6 may help lessen headaches. This vitamin helps to increase levels of the neurotransmitter serotonin in the brain, which is involved in the regulation of pain (8). However, some drugs that help migraine headaches block serotonin activity, so supplementation with B6 could in theory worsen headaches in some people.

            The mineral magnesium can be helpful for treating migraines. Study participants that supplemented with 600 mg/day of magnesium significantly reduced the frequency of migraine attacks (9). If you choose to supplement with calcium and vitamin D, include a moderate amount of magnesium (600 mg/day or less). At least half of migranes are linked in some way to magnesium (4), but very high doses of magnesium are usually needed to actually help migraine symptoms. Do not supplement with more than 500 mg/day of magnesium without notifying your physician. Although chocolate has a good amount of the mineral magnesium, which helps migraine symptoms, it also contains a chemical called phenylethylamine, which can cause headaches (4).

            Essential fatty acids (EFA’s), such as gamma-linoleic acid (GLA) and alpha-linolenic acid (ALA) may help migraine attacks. The above EFA’s administered to migraine sufferers resulted in 86% less duration, severity, and frequency of migraines (10). Dr. Jensen recommends flaxseed oil for EFA supplementation. White willow bark can be used as a natural alternative to aspirin. White willow bark cannot be used with synthetic aspirin or other NSAIDS such as ibuprofen. Pregnant or nursing women, diabetics, hemophiliacs, asthmatics, and people with ulcers should avoid use of white willow bark.

            Seventy percent of migraine sufferers had decreased frequency and severity of attacks after taking the herb feverfew daily (11). Feverfew should not be used with other blood-thinners such as aspirin or ibuprofen. Some people are allergic to feverfew, and so everyone should take a small dose of this herb at first, especially if they have a history of multiple allergies.The herb black cohosh is an effective pain reliever and can be used for headaches (12). Do not use Black Cohosh for more than one month at a time, and do not use if you are on estrogen-replacement therapy, chemotherapy, are on medications for high blood pressure, or taking sedatives, heart medications, or if you are pregnant or nursing.

References:

1. Burton Goldberg Group. Alternative Medicine: The Definitive Guide. Tiburon, CA: Future Medicine Publishing, Inc., 1997.

2. Balch, P. Prescription for Nutritional Healing, 3rd Ed. Avery Books/Penguin Putnam Inc., 2000.

3. Lipton, R., et. al. Aspartame as a dietary trigger of headache. Headache (1989), 29: 90-92.

4. Feinstein, A. Healing with Vitamins. Emmaus, PA: Rodale Books, Inc., 1996.

5. Werbach, M. Nutritional Influences on Illness, 2nd Ed. Tarzana, CA: Third Line Press, 1996.

6. Litin, S., ed. Mayo Clinic Family Health Book, 3rd Ed. New York, NY: HarperCollins Books, 2003.

7. PDR for Nutritional Supplements. Montvale, NJ: Thomson PDR, 2001.

8. Berstein, A. Vitamin B6 in clinical neurology. Annals of the New York Academy of Sciences (1990) 585: 250-260.

9. Peikert, A., Wilimzin, C., & Kohne, R. prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia (1996) Jun 16: 4, 257-263.

10. Wagner, W. & Nootbaar, U. Prophylactic treatment of migraine with gamma-linolenic and alpha-linoleic acids. Cephalalgia (1997) Apr, 17: 2, 127-130.

11. Johnson, E., et. al. Efficacy of feverfew as prophylactic treatment of migraine. British Medical Journal (1985) Aug, 291(6495): 569-573.

12. Kim, S., & Kim, M. Inhibitory effects of Cimifugae rhizome extracts on histamine, bradykinin, and cox-2 mediated inflammatory actions. Phytotherapy Research (2000) 14(8): 596-600.



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Medication for Treating a Depression

March 5th, 2011
James Bukovsky asked:




The type of medicines that are used to treat some types depressions are generally known as antidepressants. Many people who are suffering for example from bipolar disorder are generally prescribed some type on antidepressants by their doctor. The reason why these type of medications are prescribes is because of the effect it has on neurotransmitters.

By giving patients antidepressants it can increase the level of neurotransmitters which are a certain type of chemical in the brain. Research has indicated that by increasing the level of neurotransmitters in a patient it can actually help them recover from their situation.

There are actually a variety of different sorts of this type of medication on the market and I will briefly review for you the most common ones.

Selective Serotonin Reuptake Inhibitors

Selective serotonin reuptake inhibitors are also known as SSRIs and they are one of the newest types of antidepressants to have hit the market. This particular medication helps to change the level of serotonin which is a chemical which is found in the brain.

Tricyclic Antidepressants

Tricyclic antidepressants are also known as TCSs and it is one of the oldest medicines on the market which are used to combat depressions. One of the main issues however with this particular type of medication is that there are a large number of side effects which are associated with it. That is why TCS’s are generally no longer the preferred type of antidepressants used by health care providers. Tricyclic antidepressants are used to alter the level of both serotonin and norepinephrine.



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Hormone Replacement Therapy (hrt) and Alternatives

March 5th, 2011
John Russell asked:




Hormone replacement therapy (HRT) is an appropriate choice for some, but not all, women. On the benefit side, hormone replacement therapy (HRT) relieves hot flashes, night sweats, vaginal dryness, and it may improve sleep, mood, and concentration. But there are also risks with hormone replacement therapy (HRT), including higher rates of breast cancer, stroke, blood clots in the legs and lungs, and (for older women) coronary heart disease. Moderate to severe symptoms, which affect about one in five newly menopausal women, are the only compelling reason to take hormone replacement therapy (HRT).

Evidence indicates that a woman’s age and time since menopause (on average at the age of 51 in the US), along with her personal health status, influence the risk-benefit balance. The best candidate for hormone replacement therapy (HRT) is a younger, recently menopausal woman, one whose final menstrual period occurred less than five years earlier, who isn’t at high risk of heart disease, stroke, or blood clots.

To minimize risks, take the lowest dose of hormone replacement therapy (HRT) needed to make your hot flashes or night sweats tolerable. Low-dose preparations often provide relief comparable to standard-dose preparations. Hormone replacement therapy (HRT) is best used for only 2-3 years and generally no more than 5 years. Hot flashes and night sweats often peak in the first few years after the final menstrual period and then taper off, so most women won’t need hormone replacement therapy (HRT) for long-term relief.

Hormone replacement therapy (HRT) is not the only way to cool hot flashes. Layered clothing, portable fans, exercise, and paced respiration or other relaxation techniques can be very helpful, as can avoiding cigarettes, caffeine, alcohol, and spicy foods. Alternatives to hormone replacement therapy (HRT) are soy, some botanicals, certain antidepressants, and the antiseizure medication gabapentin may be beneficial for some women. All women should try at least some of these strategies before considering hormone replacement therapy (HRT).

Hormone replacement therapy (HRT) has long been the medical standard, however, hormone replacement therapy (HRT) is now questionable to side effects.

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