Posts Tagged ‘Nortriptyline’

Diabetic Peripheral Neuropathy Pain Treatment

December 7th, 2010
Alexander Krakovsky asked:




In the United States the prevalence of overweight and obesity dramatically increasing the incidence of diabetes. According to W.H.O. in the year of 2010 it would be 220 million people with diabetes worldwide. This statistics demonstrate the necessity of physician education not only in the treatment of diabetes but also in the managing of diabetes complications. Nearly a quarter of diabetes patient is already suffering from diabetic peripheral neuropathy and up to 50% of all diabetics develop peripheral neuropathy after 25 years of having this disease. Patients with diabetic peripheral neuropathy often presenting with pain that characterize as burning, aching, tingling, cold, allodynia and/or numbness.

There are numerous therapeutic agents are available but there is no single therapeutic agent available that is without adverse side effect and it is completely effective for the general diabetic population. Tricyclic antidepressants such as amitriptyline, imipramine, desipramine, and nortriptyline are useful in treatment of diabetic neuropathy. Pregabaline, gabapentin, tramadol and many others also are available for the treatment of diabetic peripheral neuropathy. When the right agent is determined, it does not necessarily relieve the pain in 100%. The physician must manage the patient on multiple levels using all available modalities in multi-functional strategy to alleviate initial pain and manage progression to other complications.

Percutaneous minimum invasive pain management technique is part of continuous strategy of permanent pain treatment that is widely use in nova days implanting the leads into epidural space and connecting them to subcutaneously positioned of spinal cord stimulator. Spinal cord stimulation applies electrical current in the form of short bursts or pulses to a specific area of the spinal cord. The pain control is very satisfactory in peripheral diabetic neuropathy patient population. Spinal Cord Stimulation has been used for many patients with failed back surgery syndrome after laminectomy as an alternative to re-operation. It has also been used to treat Complex Regional Pain Syndrome (former Reflex Sympathetic Dystrophy), post herpetic neuralgia, spinal cord injury and many others.

Traditionally, Neurostimulation was reserved as a late modality in the pain treatment continuum. In nova days, Spinal Cord Stimulation treatment implementing in pain treatment in earlier stage can enhance multidisciplinary care by facilitating participation in activities, such as physical therapy, which is essential for rehabilitation.



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Remedies For Agitated Nerve Pain – Pain Relief

November 11th, 2010
Raymond Attebery asked:




Causes of nerve pain are numerous but the main ones include:

-Damaged and/or compressed nerves due to a traumatic event such as a fall,
-Nerve damage following surgery,
-Sciatica,
-Plantar fasciitis or foot pain in general,
-Fibromyalgia, pain in the muscles, ligaments, and tendons,
-Nerve damage caused by drug abuse,
-Post-herpetic Neuralgia (PHN), the onset pain from the Shingles Rash,
-Diabetes, neuropathy and neuropathic pain.

To get pain relief, you have several options, but none of them work all the time, and most are not without risk to your body one way or the other. The body has the unique ability to adjust to most medications, in that, over time given sustained use; it requires more and more of the same pain relief medicine to achieve the same level of pain relief.

The National Institute of Diabetes and Digestive and Kidney diseases reports that over the counter NSAIDS such as aspirin, ibuprofen and the like may temporarily ease your pain but their use is not without risk to other areas of your body. Any product with capsaicin as an ingredient may offer temporary pain relief. Certain depressants such as amitriptyline, imipramine, or nortriptyline are sometimes effective. Clinical trials indicate that Mexiletine is effective in treating pain. Codeine can be used for a short time to relieve pain, but it can be very addictive. Homeopathic Drugs and Applications can be very effective. Alternative medicines such as Menastil, EZ Pain Relief and Heartland are topically applied. Other pain treatments… Acupuncture Electrical stimulation devices (TENS) Hypnosis Biofeedback



Special Note: The American Medical Association does not accept homeopathy, but it doesn’t reject it either. “The AMA encourages doctors to become aware of alternative therapies and use them when and where appropriate,” says AMA spokesman Jim Fox. “Even professionals who practice homeopathy warn that nothing in medicine–either conventional or alternative–is absolute”, states Mr. Fox.

The key to dealing with your pain is understanding the root cause of pain. ALL pain, is due to nerve damage agitation, no exceptions. The level of nerve agitation and resultant pain is directly related to the inflammation present in the painful area which reduces the level of blood and oxygen flow into the
infected area.

The most effective pain relief medications, cause the nerve ends to relax and allow the blood and oxygen to flow back into the infected area to effectively cut-off the signals to the spinal cord and therefore to the brain resulting in pain relief. You still have the problem, you just do not feel it as much.

Non-narcotic, non-addictive, all natural pain relief medications are available from The Centre for Pain Relief. Check out their website to determine if one of their products can help you with your painful condition.

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New Fibromyalgia Treatment: A Breach In Pain

September 3rd, 2010
Jerry Newman asked:




The first step in fibromyalgia treatment is to fix the sleep disturbance or problem of the patient with the use of tricyclics.  Amitriptyline (10–50 mg), nortriptyline (10–75 mg), and doxepin (10–25 mg) are the commonly used tricyclics. A similar drug based on pharmacology, cyclobenzaprine (10–40 mg), taken one to two hours before bedtime will put the patient’s sleep at stage 4, resulting in clinical improvements. Patients are given these drugs at a minimum dose but if needed, dose given is increased slowly. Patients should be informed of these drug’s side effects such as stomach and intestinal problems, dry mouth, gaining weight, sleepiness, and difficulty in thinking. Trazodone is also given, as well as zolpidem, as these improve the quality of sleep.

If the patient complains of restless leg syndrome, clonazepam may be effective. For depression and anxiety, duloxetine has shown benefit. It is a serotonin norepinephrine reuptake inhibitor (SNRI) drug. Fluoxetine, sertraline, paroxetine, citalopram, or other newer selective serotonin reuptake inhibitors can be used as antidepressants. Other useful antidepressants are trazodone and venlafaxine. Alprazolam and lorazepam are effective for anxiety. Sometimes, a psychiatric counseling is advised.

Regular aerobic exercises, which are started after patients begin to have improved sleep and less pain and fatigue, are beneficial. Exercise is started at a low impact and low level type. After the patient has tolerated it, s/he should be exercising 20–30 min, 3–4 days a week. Regular stretching exercises are also very important.

Other fibromyalgia treatments include heat, massage, injection on tender sites with steroids or lidocaine, and acupuncture. These, however, provide only temporary relief of symptoms. Newer therapies that may help to varying degrees include biofeedback, cognitive-behavioral therapy, hypnotherapy, and stress management and relaxation response training.

Biofeedback is a treatment procedure in which patients are going to learn to improve their health by own identification of signals from their own bodies. It helps patients to cope with their pain. One commonly used type of machine picks up electrical signals in the muscles and translates it into a form that patients can detect such as a flashing light bulb or a beeper.  If patients become tensed and wanted to relax muscles, they try to slow down the flashing or beeping.

Cognitive-behavioral therapy assumes that maladaptive or faulty thinking patterns cause maladaptive behavior and negative emotions. In the course of therapy, the patient is taught of changing his/her thoughts and attitudes about going to bed as well as his/her behavior on establishing a better nighttime routine.

Hynotherapy puts the patient in an extremely relaxed state to be able to use the therapist’s power of suggestion to trigger changes in the brain that are believed to improve both physical and mental health. This has helped people with refractory fibromyalgia.

Stress management and relaxation response training help reduce the amount of stress an individual experiences that may be related to the chronic pain associated with fibromyalgia. Stress does not cause fibromyalgia but it can contribute to worsen the case. Eliminating stress and allowing relaxation can lessen fibromyalgia’s symptoms and give a patient an overall better quality of life.

Patients may benefit from a multidisciplinary team approach. Group therapy may be more encouraging for the patient to undergo combination therapies. Patients should be taught to realize the importance of self-help in their condition.



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